首发精神分裂症患者磁共振成像扫描中透明隔异常
Abnormalities of the septum pellucidum on MR scans in first-episode schizophrenic patients.
作者信息
Degreef G, Lantos G, Bogerts B, Ashtari M, Lieberman J
机构信息
Department of Psychiatry, Hillside Hospital Division of the Long Island Jewish Medical Center, Albert Einstein College of Medicine, Glen Oaks, NY 11004.
出版信息
AJNR Am J Neuroradiol. 1992 May-Jun;13(3):835-40.
PURPOSE AND METHODS
Cavities in the septum pellucidum have been widely regarded in clinical neurology or in autopsy series as incidental findings of little clinical importance; however, an association between this developmental anomaly and a diagnosis of psychosis has been reported. We compared MR brain scans of schizophrenic patients with normal control subjects to determine the prevalence of this finding in the two groups:
RESULTS
A cavum septum pellucidum was found in 14 of 62 (23%) schizophrenic patients and only one of 46 control subjects (2%). Pronounced enlargement of the cavum septum and a cavum vergae were seen only in two schizophrenic subjects. A partial agenesis of the corpus callosum was also seen in one of the schizophrenic cases with the largest cavum septum pellucidum.
CONCLUSIONS
The increased prevalence of a cavum septum pellucidum, the cavum vergae, and partial callosal agenesis in schizophrenics support the hypothesis that anomalous development of the brain is an important aspect of this disorder. The disturbed structures are closely linked developmentally to the limbic system which has been implicated etiologically in studies of schizophrenia.
目的与方法
在临床神经学或尸检系列中，透明隔腔一直被广泛视为临床意义不大的偶然发现；然而，已有报道称这种发育异常与精神病诊断之间存在关联。我们比较了精神分裂症患者与正常对照者的脑部磁共振扫描，以确定两组中这一发现的发生率：
结果
62例精神分裂症患者中有14例（23%）发现有透明隔腔，而46例对照者中仅有1例（2%）发现有透明隔腔。仅在2例精神分裂症患者中观察到透明隔腔和穹窿腔明显扩大。在透明隔腔最大的1例精神分裂症病例中还发现了胼胝体部分发育不全。
结论
精神分裂症患者中透明隔腔、穹窿腔及胼胝体部分发育不全的发生率增加，支持了大脑发育异常是该疾病重要方面的假说。这些结构紊乱在发育上与边缘系统密切相关，而在精神分裂症研究中边缘系统在病因学上已被涉及。
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