Willemse T, Mudde M, Josephy M, Spruijt B M
Institute of Molecular Biology, University of Utrecht, The Netherlands.
Eur Neuropsychopharmacol. 1994 Mar;4(1):39-45. doi: 10.1016/0924-977x(94)90313-1.
In a double-blind cross-over study the effect of a single injection of naloxone (1 mg/kg s.c.) was investigated in 12 cats which suffered from excessive grooming with subsequent coat damage. Based on clinical observations and reports of the owners, naloxone had a beneficial effect on grooming which lasted between 2.5 weeks and 6 months (median 3 months). In another double-blind placebo-controlled study the effect of a single injection of haloperidol (2 mg/kg i.v.) was investigated in 20 cats with excessive grooming. Within 24 h haloperidol significantly reduced the time spent grooming. Four months after the injection no effect remained in nine of 10 cats injected with a placebo solution, whereas six of 10 cats injected with haloperidol the improved condition of the coat was maintained. It is hypothesized that naloxone is only effective in counteracting recently developed stereotypic behaviors and that haloperidol rather reduces stereotyped behaviors over a longer period.
在一项双盲交叉研究中，对12只因过度梳理导致毛发受损的猫进行了单次皮下注射纳洛酮（1毫克/千克）效果的研究。根据临床观察和猫主人的报告，纳洛酮对梳理行为有有益影响，持续时间在2.5周至6个月之间（中位数为3个月）。在另一项双盲安慰剂对照研究中，对20只过度梳理的猫进行了单次静脉注射氟哌啶醇（2毫克/千克）效果的研究。在24小时内，氟哌啶醇显著减少了梳理所花费的时间。注射四个月后，注射安慰剂溶液的10只猫中有9只不再有效果，而注射氟哌啶醇的10只猫中有6只毛发状况得到改善并得以维持。据推测，纳洛酮仅在抵消近期出现的刻板行为方面有效，而氟哌啶醇在更长时间内更能减少刻板行为。
