Van Wimersma Greidanus T B, Maigret C
Rudolf Magnus Institute of Pharmacology, University of Utrecht, The Netherlands.
Eur J Pharmacol. 1988 Sep 13;154(2):217-20. doi: 10.1016/0014-2999(88)90102-1.
The intracerebroventricular (i.c.v.) administration of substance P elicits in rats an excessive grooming that is characterized by body grooming, anogenital grooming and scratching. The total grooming scores displayed by rats treated with substance P hardly exceeded 23% of the theoretical maximal grooming score. Substance P-induced excessive grooming was suppressed by pretreatment with naloxone, haloperidol on neurotensin. It is concluded that substance P induces excessive grooming with a pattern different from that of grooming elicited by other peptides.
向大鼠脑室内注射P物质会引发过度梳理行为，其特征为身体梳理、肛门生殖器梳理和抓挠。接受P物质治疗的大鼠所表现出的总梳理得分几乎未超过理论最大梳理得分的23%。用纳洛酮、氟哌啶醇或神经降压素预处理可抑制P物质诱导的过度梳理行为。结论是，P物质诱导的过度梳理行为模式与其他肽类引发的梳理行为模式不同。
