癌症化疗：寻找新型抗癌药物。
Cancer chemotherapy: identifying novel anticancer drugs.
作者信息
Carmichael J
机构信息
CRC Academic Unit of Clinical Oncology, Nottingham City Hospital.
出版信息
BMJ. 1994 May 14;308(6939):1288-90. doi: 10.1136/bmj.308.6939.1288.
Abstract
There are now around 60 cytotoxic drugs licensed for use in cancer therapy in the United Kingdom. For certain malignancies such as childhood cancers, haematological malignancies, and germ cell tumours chemotherapy has been pivotal to the substantial improvement in therapeutic outcome achieved over the past 10 years. In contrast, improvements in the systemic management of adult solid tumours have been less dramatic. There is a clear and urgent need for new, more effective drugs for lung, breast, and colorectal malignancies. This paper examines the processes in identifying, developing, and evaluating new drugs with anticancer activity.
摘要
目前在英国约有60种细胞毒性药物被批准用于癌症治疗。对于某些恶性肿瘤，如儿童癌症、血液系统恶性肿瘤和生殖细胞肿瘤，化疗对于过去10年治疗效果的显著改善起到了关键作用。相比之下，成人实体瘤全身治疗方面的进展则没那么显著。对于肺癌、乳腺癌和结直肠癌，显然迫切需要新的、更有效的药物。本文探讨了识别、开发和评估具有抗癌活性的新药的过程。
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