Yahia L H, Drouin G, Zukor D
Institut de génie biomédical, Ecole Polytechnique de Montréal, Québec, Canada.
Biomed Mater Eng. 1993 Winter;3(4):211-21.
In this study, the effect of sterilization was investigated on the mechanical properties of rabbit's meniscal grafts. The processes of freezing and irradiation were carried out and their effects upon the elastic and viscoelastic properties measured using a tensile testing machine and an indentation test. It was found that gamma irradiation, at dosages commonly used for sterilizing grafts, had a significant adverse influence on the elastic and viscous response of the grafts. Freezing led also to a small significant decrease in elastic stiffness but no change in failure strength. It is concluded that irradiation sterilization is unsuitable for clinical use and other techniques should be used whenever possible.
在本研究中，研究了灭菌对兔半月板移植物力学性能的影响。进行了冷冻和辐照过程，并使用拉伸试验机和压痕试验测量了它们对弹性和粘弹性性能的影响。结果发现，常用于移植物灭菌的剂量的伽马辐照对移植物的弹性和粘性反应有显著的不利影响。冷冻也导致弹性刚度有小幅显著下降，但破坏强度没有变化。得出的结论是，辐照灭菌不适用于临床应用，应尽可能使用其他技术。
