Mathew P, Bozeman P, Krance R A, Brenner M K, Heslop H E
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Bone Marrow Transplant. 1994 Feb;13(2):221-3.
Three pediatric patients of a cohort of 24 who underwent allogeneic bone marrow transplantation (BMT) from matched unrelated or mismatched family member donors developed low grade fever and cough between 2 and 3 months after BMT in the absence of clinical GVHD. Imaging studies revealed bilateral patchy opacities and open lung biopsies revealed the characteristic histological appearance of bronchiolitis obliterans organizing pneumonia. All three patients were treated with steroids and in two patients the syndrome resolved over 1-2 months; the third patient developed progressive pulmonary failure and died 2 weeks after diagnosis. BOOP may be an under-recognized respiratory complication following BMT from a matched unrelated donor or mismatched family member.
在一组24例接受来自匹配的无关供体或不匹配家庭成员供体的异基因骨髓移植（BMT）的儿科患者中，有3例在BMT后2至3个月出现低热和咳嗽，且无临床移植物抗宿主病（GVHD）。影像学检查显示双侧斑片状模糊影，开放性肺活检显示闭塞性细支气管炎伴机化性肺炎的特征性组织学表现。所有3例患者均接受了类固醇治疗，其中2例患者的综合征在1至2个月内得到缓解；第3例患者出现进行性肺衰竭，诊断后2周死亡。闭塞性细支气管炎伴机化性肺炎可能是来自匹配的无关供体或不匹配家庭成员的BMT后一种未被充分认识的呼吸道并发症。
