Mulvany M J
Danish Biomembrane Research Centre, Aarhus University.
Blood Press Suppl. 1994;1:11-7.
In essential hypertension, the structure of the resistance vessels is altered such that the internal diameter (lumen) is reduced and the ratio of the tunica media thickness to the lumen is increased. This abnormality appears to be associated more with remodelling than with growth. Thus, normalization of resistance vessel structure must be aimed both at reversing the remodelling as well as inhibiting growth. Present evidence concerning the effect of antihypertensive therapy on vascular structure suggests that the effect of such therapy on vascular structure is due more to remodelling than to growth inhibition. However, the effect on vascular structure appears to be insufficient as antihypertensive therapy is better able to reduce blood pressure than to normalize vascular structure. It is suggested that the possible role of vascular remodelling in essential hypertension requires further work, and that this may have consequences for future strategies in the development of antihypertensive drugs.
在原发性高血压中，阻力血管的结构发生改变，致使内径（管腔）减小，中膜厚度与管腔的比值增加。这种异常似乎更多地与重塑有关，而非生长。因此，阻力血管结构的正常化必须旨在逆转重塑以及抑制生长。目前关于抗高血压治疗对血管结构影响的证据表明，此类治疗对血管结构的影响更多是由于重塑，而非生长抑制。然而，抗高血压治疗对血管结构的影响似乎并不充分，因为其降低血压的能力优于使血管结构正常化的能力。有人提出，血管重塑在原发性高血压中可能发挥的作用需要进一步研究，这可能会对未来抗高血压药物的研发策略产生影响。
