类风湿关节炎中甲氨蝶呤的血清结合情况。
Methotrexate serum binding in rheumatoid arthritis.
作者信息
Claudepierre P, Urien S, Chevalier X, Chassany O, Larget-Piet B, Tillement J P
机构信息
Laboratoire de Pharmacologie, Faculté de Médecine, Créteil, Université Paris, France.
出版信息
Int J Clin Pharmacol Ther. 1994 Mar;32(3):113-5.
The serum binding of methotrexate was determined by equilibrium dialysis using radiolabelled methotrexate. Methotrexate was only albumin-bound in serum. The binding was 46% in controls versus 42% in rheumatoid arthritis and 44% in cancer. Serum binding was significantly decreased by salicylate and high concentration of naproxen. Hypoalbuminemia and concomitant administration of salicylate or naproxen may influence methotrexate toxicity.
使用放射性标记的甲氨蝶呤通过平衡透析法测定甲氨蝶呤的血清结合率。甲氨蝶呤在血清中仅与白蛋白结合。对照组的结合率为46%，类风湿性关节炎患者为42%，癌症患者为44%。水杨酸盐和高浓度的萘普生可显著降低血清结合率。低白蛋白血症以及同时使用水杨酸盐或萘普生可能会影响甲氨蝶呤的毒性。
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