Grande L, Toledo-Pimentel V, Manterola C, Lacima G, Ros E, García-Valdecasas J C, Fuster J, Visa J, Pera C
Department of Surgery, Hospital Clínic i Provincial, University of Barcelona, Spain.
Br J Surg. 1994 Apr;81(4):548-50. doi: 10.1002/bjs.1800810421.
A total of 160 patients treated by Nissen fundoplication for uncomplicated gastro-oesophageal reflux disease were studied over a 20-year period. Recurrent reflux and side-effects were assessed yearly after surgery. No objective tests for reflux were performed during follow-up if patients were asymptomatic. Perioperative mortality and technique-related morbidity rates were both 2 per cent. At the latest evaluation, 79 per cent of patients were completely relieved of reflux symptoms, 85 per cent had symptoms of Visick grade 1 or 2 and 89 per cent would be willing to undergo surgery again under the same conditions. Actuarial analysis showed that the success rate of fundoplication was 92 per cent at 20 years. Fourteen patients (9 per cent) developed side-effects after fundoplication and had continuing disability. Nissen fundoplication achieves permanent control of reflux symptoms in most patients with few complications and has a high degree of patient satisfaction.
在20年的时间里，对160例因单纯性胃食管反流病接受nissen胃底折叠术治疗的患者进行了研究。术后每年评估反流复发情况和副作用。如果患者无症状，随访期间不进行反流的客观检查。围手术期死亡率和技术相关发病率均为2%。在最近一次评估中，79%的患者反流症状完全缓解，85%的患者有Visick 1级或2级症状，89%的患者愿意在相同条件下再次接受手术。精算分析显示，胃底折叠术20年的成功率为92%。14例患者（9%）在胃底折叠术后出现副作用并持续残疾。nissen胃底折叠术能使大多数患者的反流症状得到永久性控制，并发症少，患者满意度高。
