Kelly P A, Thomas C L, Ritchie I M
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK.
Brain Res. 1994 Mar 14;639(2):309-12. doi: 10.1016/0006-8993(94)91744-2.
Cerebral blood flow and glucose utilization were measured in rat neocortex, using [14C]iodoantipyrine and 2-deoxy-D-[14C]glucose quantitative autoradiography, respectively, following nitric oxide synthesis inhibition with L-NAME. In intact animals cortical blood flow was decreased, despite increased arterial blood pressure above autoregulatory limits, whilst glucose use remained unaffected. Unilateral sympathectomy at the superior cervical ganglion had no effect, suggesting that the autoregulatory response to L-NAME-induced hypertension is independent of sympathetic activity.
在使用L-NAME抑制一氧化氮合成后，分别采用[14C]碘安替比林和2-脱氧-D-[14C]葡萄糖定量放射自显影法，测定大鼠新皮质的脑血流量和葡萄糖利用率。在完整动物中，尽管动脉血压升高超过了自动调节极限，但皮质血流量仍减少，而葡萄糖利用情况未受影响。对上颈神经节进行单侧交感神经切除术没有效果，这表明对L-NAME诱导的高血压的自动调节反应独立于交感神经活动。
