Cafiero M, Strumia E, Pirone S, Pacileo S, Santoro R
I Divisione di Medicina Interna, USL 41, Ospedale V. Monaldi, Napoli.
Clin Ter. 1994 Apr;144(4):321-8.
The hemodynamic effects of acute and long-term administration of creatine phosphate were studied in 23 patients with heart failure (NYHA classes II and III) under stabilized treatment. Acute creatine phosphate (5 g i.v.) induced a significant increase of the ejection fraction (FE) and of other parameters of cardiac contractility. Once these improvements of cardiac contractility were obtained by acute treatment, further significant increases in cardiac function were observed if treatment was continued for six days, i.e. telesystolic diameter and volume, as well as parietal stress were significantly reduced, and ejection fraction and shortening fraction were significantly increased. Creatine phosphate treatment has a favourable influence on the hemodynamics of patients with an obvious contractility deficit and chronic ischemia of the myocardium.
在23例接受稳定治疗的心力衰竭（纽约心脏协会II级和III级）患者中，研究了急性和长期给予磷酸肌酸的血流动力学效应。急性给予磷酸肌酸（5克静脉注射）可使射血分数（FE）和其他心脏收缩性参数显著增加。通过急性治疗获得这些心脏收缩性改善后，如果继续治疗6天，可观察到心脏功能进一步显著改善，即收缩末期直径和容积以及壁应力显著降低，射血分数和缩短分数显著增加。磷酸肌酸治疗对心肌收缩力明显不足和慢性缺血患者的血流动力学有有利影响。
