Jack C R
Mayo Clinic Foundation, Department of Diagnostic Radiology, Rochester, Minnesota 55905.
Epilepsia. 1994;35 Suppl 6:S21-9. doi: 10.1111/j.1528-1157.1994.tb05986.x.
In the study of brain morphometry, it is accepted that a relationship exists between brain structure and function, both normal and abnormal. One descriptor of morphometric structure is volume. Abnormalities in hippocampal morphology, including unilateral or bilateral volume loss, are known to occur in epilepsy, Alzheimer's disease, and in certain amnestic syndromes. Precise quantitation should improve understanding of the role of any biologic system in normal function and in disease. The objectives of magnetic resonance (MR)-based hippocampal volume measurements are precise quantitation, identification of a normal range, and identification of the association between biologic variables and aberrations in this volumetric parameter. Volumetric measures introduce a level of precision in the estimation of hippocampal size that is not available simply by visually inspecting a set of MR images, thus enabling statistically based hypothesis testing. To produce accurate hippocampal volume measurements with magnetic resonance imaging (MRI), attention must be directed to the two major components of the operation as a whole, MR image acquisition and image processing.
在脑形态测量学研究中，人们公认脑结构与功能之间存在着一种关系，包括正常和异常情况。形态测量结构的一个描述指标是体积。已知在癫痫、阿尔茨海默病和某些遗忘综合征中会出现海马形态异常，包括单侧或双侧体积减小。精确的定量分析应有助于更好地理解任何生物系统在正常功能和疾病中的作用。基于磁共振（MR）的海马体积测量的目标是精确的定量分析、确定正常范围以及确定生物变量与该体积参数异常之间的关联。体积测量在估计海马大小时引入了一种简单通过目视检查一组MR图像无法获得的精确程度，从而能够进行基于统计的假设检验。为了通过磁共振成像（MRI）获得准确的海马体积测量结果，必须关注整个操作的两个主要组成部分，即MR图像采集和图像处理。
