Kraemer D L, Awad I A
Section of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510.
Epilepsia. 1994;35 Suppl 6:S30-43. doi: 10.1111/j.1528-1157.1994.tb05987.x.
Vascular malformations (VMs) are associated with epilepsy. The natural history of the various VMs, clinical presentation, and tendency to provoke epilepsy determine treatment strategies. Investigations have probed the mechanisms of epileptogenesis associated with these lesions. Electrophysiologic changes are associated with epileptogenic cortex adjacent to VMs. Putative pathophysiologic mechanisms of epileptogenesis include neuronal cell loss, glial proliferation and abnormal glial physiology, altered neurotransmitter levels, free radical formation, and aberrant second messenger physiology.
血管畸形（VMs）与癫痫有关。各种VMs的自然病史、临床表现以及诱发癫痫的倾向决定了治疗策略。研究已经探究了与这些病变相关的癫痫发生机制。电生理变化与VMs附近的致痫皮层有关。癫痫发生的假定病理生理机制包括神经元细胞丢失、胶质细胞增殖和异常的胶质细胞生理学、神经递质水平改变、自由基形成以及异常的第二信使生理学。
