Wagner G F, Jaworski E
Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada.
Mol Cell Endocrinol. 1994 Mar;99(2):315-22. doi: 10.1016/0303-7207(94)90023-x.
Stanniocalcin (STC) is an inhibitor of gill calcium transport produced by the corpuscles of Stannius (CS), endocrine glands in bony fishes. In previous studies we have described how STC secretion is regulated by calcium both in vitro and in vivo, using rainbow trout as a model system. In this report we have examined the effects of calcium on STC mRNA levels in primary cultured trout CS cells. The results show that message levels are positively regulated by extracellular calcium concentrations within the physiological range. The calcium response was also temporally-related as more prolonged exposures tended to have greater effects. Similar concentrations of magnesium had no effect on message levels. This represents another level at which calcium regulates the CS cell, in addition to its established effects on STC synthesis and secretion. The results are discussed in relation to the other known calciotropic hormones, calcitonin and parathyroid hormone.
鲽鱼降钙素（STC）是由硬骨鱼类的斯坦尼氏小体（CS）产生的鳃钙转运抑制剂，CS是硬骨鱼类的内分泌腺。在之前的研究中，我们以虹鳟鱼作为模型系统，描述了STC分泌在体外和体内是如何受钙调节的。在本报告中，我们研究了钙对原代培养的鳟鱼CS细胞中STC mRNA水平的影响。结果表明，在生理范围内，细胞外钙浓度对信息水平具有正向调节作用。钙反应也与时间相关，因为更长时间的暴露往往具有更大的影响。相似浓度的镁对信息水平没有影响。这代表了钙调节CS细胞的另一个层面，除此之外，钙对STC的合成和分泌也有既定的影响。我们将结合其他已知的钙调节激素——降钙素和甲状旁腺激素来讨论这些结果。
