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Restoration of CTL recognition of a mutant FMP peptide by a compensatory change in HLA-A2.

作者信息

Matsui M, Frelinger J A

机构信息

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599-7290.

出版信息

Immunogenetics. 1994;40(1):66-9. doi: 10.1007/BF00163966.

DOI:10.1007/BF00163966
PMID:8206528
Abstract
摘要

相似文献

1
Restoration of CTL recognition of a mutant FMP peptide by a compensatory change in HLA-A2.
Immunogenetics. 1994;40(1):66-9. doi: 10.1007/BF00163966.
2
Genetic evidence for difference between intracellular and extracellular peptides in influenza A matrix peptide-specific CTL recognition.甲型流感病毒基质肽特异性CTL识别中细胞内和细胞外肽差异的遗传学证据。
J Immunol. 1995 Feb 1;154(3):1088-96.
3
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A single amino acid substitution in HLA-A2 can alter the selection of the cytotoxic T lymphocyte repertoire that responds to influenza virus matrix peptide 55-73.HLA - A2中的单个氨基酸替换可改变对流感病毒基质肽55 - 73产生应答的细胞毒性T淋巴细胞库的选择。
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Influenza A-specific, HLA-A2.1-restricted cytotoxic T lymphocytes from HLA-A2.1 transgenic mice recognize fragments of the M1 protein.来自HLA - A2.1转基因小鼠的甲型流感特异性、HLA - A2.1限制性细胞毒性T淋巴细胞识别M1蛋白的片段。
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Residues outside of the HLA-A2 peptide-binding groove can abrogate or enhance recognition of influenza virus matrix peptide pulsed cells by cytotoxic T lymphocytes.HLA - A2肽结合槽外的残基可消除或增强细胞毒性T淋巴细胞对流感病毒基质肽脉冲细胞的识别。
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Positioning of a peptide in the cleft of HLA-A2 by complementing amino acid changes.通过互补氨基酸变化将一种肽定位在HLA - A2的裂隙中。
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The kinetics of peptide binding to HLA-A2 and the conformation of the peptide-A2 complex can be determined by amino acid side chains on the floor of the peptide binding groove.肽与HLA - A2结合的动力学以及肽 - A2复合物的构象可由肽结合槽底部的氨基酸侧链来确定。
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Comparison between two peptide epitopes presented to cytotoxic T lymphocytes by HLA-A2. Evidence for discrete locations within HLA-A2.
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引用本文的文献

1
HLA-A2 subtypes are functionally distinct in peptide binding and presentation.HLA - A2亚型在肽结合和呈递方面功能各异。
J Exp Med. 1995 Dec 1;182(6):1847-56. doi: 10.1084/jem.182.6.1847.

本文引用的文献

1
Analysis of mutant HLA-A2 molecules. Differential effects on peptide binding and CTL recognition.
J Immunol. 1994 Feb 1;152(3):1213-21.
2
Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide.I类主要组织相容性复合体蛋白中特定等位基因的B口袋移植改变了对肽P2位锚定残基的要求。
Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6879-83. doi: 10.1073/pnas.90.14.6879.
3
Roles of the six peptide-binding pockets of the HLA-A2 molecule in allorecognition by human cytotoxic T-cell clones.HLA - A2分子的六个肽结合口袋在人细胞毒性T细胞克隆的同种异体识别中的作用。
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):674-8. doi: 10.1073/pnas.90.2.674.
4
Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28.BB7.2的部分纯化及某些特性。一种对HLA - A2和HLA - A28变体具有特异性的细胞毒性单克隆抗体。
Hum Immunol. 1981 Dec;3(4):277-99. doi: 10.1016/0198-8859(81)90065-3.
5
A monoclonal antibody that recognizes an antigenic determinant shared by HLA A2 and B17.一种识别HLA A2和B17共有的抗原决定簇的单克隆抗体。
Hum Immunol. 1980 Sep;1(2):121-9. doi: 10.1016/0198-8859(80)90099-3.
6
NK susceptibility varies inversely with target cell class I HLA antigen expression.自然杀伤细胞（NK）的敏感性与靶细胞I类人类白细胞抗原（HLA）的表达呈负相关。
J Immunol. 1987 Mar 15;138(6):1657-9.
7
Association of class I major histocompatibility heavy and light chains induced by viral peptides.病毒肽诱导的I类主要组织相容性重链和轻链的关联
Nature. 1989 Aug 10;340(6233):443-8. doi: 10.1038/340443a0.
8
Specificity pockets for the side chains of peptide antigens in HLA-Aw68.HLA-Aw68中肽抗原侧链的特异性口袋
Nature. 1989 Dec 7;342(6250):692-6. doi: 10.1038/342692a0.
9
Antigen recognition by class I-restricted T lymphocytes.I类限制性T淋巴细胞的抗原识别
Annu Rev Immunol. 1989;7:601-24. doi: 10.1146/annurev.iy.07.040189.003125.
10
Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes.HLA - A2的突变和变异对细胞毒性T淋巴细胞识别病毒肽表位的影响。
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9194-8. doi: 10.1073/pnas.85.23.9194.