Bertelli G, Dini D, Forno G B, Gozza A, Silvestro S, Venturini M, Rosso R, Pronzato P
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
J Cancer Res Clin Oncol. 1994;120(8):505-6. doi: 10.1007/BF01191807.
Skin necrosis is a recognized potential consequence of an inadvertent extravasation of Vinca alkaloids in the surrounding tissues during i.v. administration. Experimental studies suggest that hyaluronidase, an enzyme that degrades hyaluronic acid and improves the absorption of locally injected drugs, can reduce the risk of progressing to skin necrosis. On this basis, we used this enzyme as a local treatment after extravasations of Vinca alkaloids in seven patients. No patient suffered from subsequent skin necrosis. To the best of our knowledge, this is the first clinical report confirming the positive findings of experimental studies on the effectiveness of this antidote.
皮肤坏死是静脉给药过程中长春花生物碱意外外渗至周围组织时公认的潜在后果。实验研究表明，透明质酸酶是一种可降解透明质酸并改善局部注射药物吸收的酶，可降低发展为皮肤坏死的风险。在此基础上，我们对7例长春花生物碱外渗患者使用该酶进行局部治疗。所有患者均未发生后续皮肤坏死。据我们所知，这是第一份证实该解毒剂有效性实验研究阳性结果的临床报告。
