γ-吡喃酮化合物。5. 呫吨氧丙醇胺及相关化合物的合成与抗血小板作用。

gamma-Pyrone compounds. 5. Synthesis and antiplatelet effects of xanthonoxypropanolamines and related compounds.

作者信息

Liou S S, Teng C M, Ko F N, Lin C N

机构信息

Natural Products Research Center, Kaohsiung Medical College, Taiwan, R.O.C.

出版信息

J Pharm Sci. 1994 Mar;83(3):391-5. doi: 10.1002/jps.2600830325.

DOI:10.1002/jps.2600830325

PMID:8207688

Abstract

A series of simple xanthonoxypropanolamines and related compounds were synthesized. 3-[3-(Cyclopropylamino)propoxy]-xanthone showed same potent antiplatelet effects as norathyriol tetraacetate on arachidonate-induced aggregation. 3-[3-(Cyclohexylamino)-2-hydroxypropoxy]xanthone showed more potent antiplatelet effects than norathyriol tetraacetate on collagen-induced aggregation. The various amino groups of the oxypropanolamine or oxypropylamine side chains of the synthesized compounds regulated the antiplatelet effects.

摘要

合成了一系列简单的氧杂蒽氧基丙醇胺及相关化合物。3-[3-(环丙基氨基)丙氧基]氧杂蒽对花生四烯酸诱导的血小板聚集表现出与诺拉替罗四乙酸相同的强效抗血小板作用。3-[3-(环己基氨基)-2-羟基丙氧基]氧杂蒽对胶原诱导的血小板聚集表现出比诺拉替罗四乙酸更强的抗血小板作用。合成化合物的氧丙醇胺或氧丙胺侧链上的各种氨基调节了抗血小板作用。