将针对小鼠艾滋病相关肿瘤的多克隆和克隆细胞毒性T淋巴细胞（CTL）进行过继转移，可有效维持CTL反应：这是一种抵御LP-BM5逆转录病毒诱导的免疫缺陷的保护措施。
Adoptive transfer of polyclonal and cloned cytolytic T lymphocytes (CTL) specific for mouse AIDS-associated tumors is effective in preserving CTL responses: a measure of protection against LP-BM5 retrovirus-induced immunodeficiency.
作者信息
Green W R, Green K A, Crassi K M
机构信息
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756.
出版信息
J Virol. 1994 Jul;68(7):4679-84. doi: 10.1128/JVI.68.7.4679-4684.1994.
Abstract
Cytolytic T lymphocytes (CTL) can be raised against C57BL/6 B-cell lymphomas from mice with LP-BM5 murine leukemia virus-induced AIDS (MAIDS). Adoptive transfer of polyclonal anti-MAIDS tumor CTL or two CTL clones specific for the B6-1710 MAIDS lymphoma caused preservation of major histocompatibility complex-restricted and allogeneic CTL responses, which may be interpreted as indices of protection from LP-BM5 murine leukemia virus-induced immunodeficiency.
摘要
细胞溶解性T淋巴细胞（CTL）可以针对感染LP - BM5鼠白血病病毒诱发的获得性免疫缺陷综合征（MAIDS）小鼠的C57BL / 6 B细胞淋巴瘤产生。多克隆抗MAIDS肿瘤CTL或针对B6 - 1710 MAIDS淋巴瘤的两个CTL克隆的过继转移导致主要组织相容性复合体限制的和同种异体CTL反应得以保留，这可以被解释为免受LP - BM5鼠白血病病毒诱发免疫缺陷的指标。
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