H-2D对弗氏病毒白血病恢复的控制：H-2D区域影响T淋巴细胞对弗氏病毒反应的动力学。
H-2D control of recovery from Friend virus leukemia: H-2D region influences the kinetics of the T lymphocyte response to Friend virus.
作者信息
Britt W J, Chesebro B
出版信息
J Exp Med. 1983 Jun 1;157(6):1736-45. doi: 10.1084/jem.157.6.1736.
Abstract
A Friend virus (FV)-specific T lymphocyte proliferation assay was used to compare the T lymphocyte responses of H-2 congenic mice that differed in their ability to recover from FV leukemia after inoculation of high virus doses. Gene(s) of the H-2D region influenced the kinetics of this response such that H-2Db/b homozygous mice were positive 6-8 d earlier than H-2Dd/b mice. This correlated with the Rfv-1, H-2D-linked influence on recovery from FV by these mice, and also appeared to explain the prominent effect of virus dose on recovery incidence. These findings were supported by the ability of passively transferred immune splenic T lymphocytes to induce recovery from leukemia at 6 d after FV inoculation, but not at 16 d. H-2a/a mice were found to be unresponsive in the FV-specific T lymphocyte proliferation assay. This effect mapped to the left of H-2D, possibly in the H-2I region, and may be an in vitro manifestation of the Rfv-2 gene. No evidence for nonspecific immunosuppression of the T lymphocyte response to concanavalin A was observed in any of the H-2 congenic F1 mice studied.
摘要
采用脾友病毒（FV）特异性T淋巴细胞增殖试验，比较了接种高剂量病毒后从FV白血病恢复能力不同的H-2同类系小鼠的T淋巴细胞反应。H-2D区域的基因影响了这种反应的动力学，使得H-2Db/b纯合小鼠比H-2Dd/b小鼠早6 - 8天呈阳性反应。这与Rfv-1（与H-2D连锁）对这些小鼠从FV感染中恢复的影响相关，并且似乎也解释了病毒剂量对恢复发生率的显著影响。这些发现得到了如下结果的支持：被动转移的免疫脾T淋巴细胞能够在FV接种后6天而非16天诱导白血病恢复。在FV特异性T淋巴细胞增殖试验中，发现H-2a/a小鼠无反应。这种效应定位于H-2D左侧，可能在H-2I区域，并且可能是Rfv-2基因的一种体外表现。在所研究的任何H-2同类系F1小鼠中，均未观察到对伴刀豆球蛋白A的T淋巴细胞反应存在非特异性免疫抑制作用的证据。
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