通过五氟苄基溴的相转移催化衍生化，采用电子捕获气相色谱法测定氰化物、碘化物、亚硝酸盐、硫化物和硫氰酸根阴离子。
Electron-capture gas chromatographic determination of cyanide, iodide, nitrite, sulfide, and thiocyanate anions by phase-transfer-catalyzed derivatization with pentafluorobenzyl bromide.
作者信息
Chen S H, Wu S M, Kou H S, Wu H L
机构信息
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
出版信息
J Anal Toxicol. 1994 Mar-Apr;18(2):81-5. doi: 10.1093/jat/18.2.81.
A sensitive gas chromatographic method has been established for the simultaneous determination of biologically active inorganic anions, including cyanide, iodide, nitrite, sulfide, and thiocyanate anions as their volatile organic derivatives. The method is based on the formation of ion pairs from the anions and a complex cryptand and on the resulting neutral ion-pair partition to an organic phase for derivatization with pentafluorobenzyl bromide. Several parameters affecting the partition and derivatization of the anions were investigated. Individual and simultaneous determination of the anions can be achieved at sub-nmol levels with an electron-capture detector. Partial application of the method for the analysis of cyanide, nitrite, and thiocyanate in real samples proved satisfactory.
已建立一种灵敏的气相色谱法，用于同时测定生物活性无机阴离子，包括氰化物、碘化物、亚硝酸盐、硫化物和硫氰酸根阴离子，这些阴离子以其挥发性有机衍生物的形式存在。该方法基于阴离子与一种络合穴醚形成离子对，并基于由此产生的中性离子对分配到有机相中，以便与五氟苄基溴进行衍生化反应。研究了影响阴离子分配和衍生化的几个参数。使用电子捕获检测器，可在亚纳摩尔水平实现阴离子的单独和同时测定。该方法在实际样品中分析氰化物、亚硝酸盐和硫氰酸盐的部分应用结果令人满意。
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