van Daele P L, Birkenhäger J C, Pols H A
Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, Netherlands.
Neth J Med. 1994 Feb;44(2):65-72.
Currently, biomarkers are available which have considerably increased the possibility of monitoring changes in bone turnover. Assays for carboxy-terminal procollagen I fragments, osteocalcin and the bone-specific isoenzyme of alkaline phosphatase allow a more precise assessment of the complex osteoblastic functions in health and disease; osteocalcin appears at present to be the most satisfactory one. With respect to bone resorption, the measurement of urinary pyridinoline cross-links seems to be the most reliable assay. It has to be emphasized, however, that a single biomarker may be of value in some metabolic bone diseases but not in others.
目前，已有生物标志物，这大大增加了监测骨转换变化的可能性。检测I型前胶原羧基末端片段、骨钙素和碱性磷酸酶的骨特异性同工酶，能够更精确地评估健康和疾病状态下复杂的成骨细胞功能；目前骨钙素似乎是最令人满意的一种。关于骨吸收，尿吡啶啉交联的测量似乎是最可靠的检测方法。然而，必须强调的是，单一生物标志物在某些代谢性骨病中可能有价值，但在其他疾病中则不然。
