Fujimura R, Ashizawa N, Watanabe M, Mukai N, Amagai H, Fukubayashi T, Hayashi K, Tokuyama K, Suzuki M
Laboratory of Biochemistry of Exercise and Nutrition, University of Tsukuba, Japan.
J Bone Miner Res. 1997 Apr;12(4):656-62. doi: 10.1359/jbmr.1997.12.4.656.
We studied the effects of high intensity resistance exercise training on bone metabolism in 17 young adult Oriental males (23-31 years) by measuring sensitive biomarkers of bone formation and resorption. The subjects were assigned to a training group and a sedentary group. The training group followed a weight training program three times per week for 4 months. In the training group, serum osteocalcin concentration and serum bone-specific alkaline phosphatase activity were significantly increased within the first month after the beginning of resistance exercise training, and the elevated levels remained throughout the training period, while there was no significant change in plasma procollagen type-I C-terminal concentration. Urinary deoxypyridinoline excretion was transiently suppressed and returned to the initial value but was never stimulated during the 4 months. These results suggest that the resistance exercise training enhanced bone formation without prior bone resorption. In the sedentary group, there was no significant difference in bone metabolic markers except plasma procollagen type-I C-terminal, which continuously decreased during the experimental period. There were no significant changes in total and regional bone mineral density in either group. In conclusion, (1) resistance exercise training increased markers of bone formation, while it transiently suppressed a marker of bone resorption, and (2) such adaptive changes of bone metabolism to resistance exercise training occurred during the early period of the training, before changes in bone density were observable through densitometry.
我们通过测量骨形成和骨吸收的敏感生物标志物，研究了高强度抗阻运动训练对17名年轻成年东方男性（23 - 31岁）骨代谢的影响。受试者被分为训练组和久坐组。训练组每周进行三次重量训练计划，持续4个月。在训练组中，抗阻运动训练开始后的第一个月内，血清骨钙素浓度和血清骨特异性碱性磷酸酶活性显著升高，且在整个训练期间一直保持升高水平，而血浆I型前胶原C末端浓度没有显著变化。尿脱氧吡啶啉排泄在4个月内短暂受到抑制并恢复到初始值，但从未受到刺激。这些结果表明，抗阻运动训练增强了骨形成，而没有先于骨吸收。在久坐组中，除血浆I型前胶原C末端外，骨代谢标志物没有显著差异，该指标在实验期间持续下降。两组的全身和局部骨密度均无显著变化。总之，（1）抗阻运动训练增加了骨形成标志物，同时短暂抑制了骨吸收标志物；（2）在通过骨密度测定可观察到骨密度变化之前，骨代谢对抗阻运动训练的这种适应性变化在训练早期就已发生。
