van Kuijck M A, Rotteveel J J, van Oostrom C G, Novakova I
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Neuropediatrics. 1994 Feb;25(1):16-9. doi: 10.1055/s-2008-1071575.
Four children with a cerebrovascular occlusive accident and protein C deficiency are described. Two patients presented with an acute hemiplegia, the others suffered from a transient ischemic attack and a progressive hydrocephalus as the result of sinus thrombosis. In all cases protein C deficiency, Type 1, was diagnosed. Other causes of cerebrovascular disease were excluded. Although venous thrombosis has been extensively reported in protein C deficiency, these cases indicate that protein C deficiency is also related to arterial thrombosis. In evaluating children with cerebrovascular accidents, protein C deficiency should also be considered.
