Camerlingo M, Finazzi G, Casto L, Laffranchi C, Barbui T, Mamoli A
Divisione di Neurologia 2a, Ospedali Riuniti, Bergamo, Italy.
Neurology. 1991 Sep;41(9):1371-3. doi: 10.1212/wnl.41.9.1371.
Out of a consecutive series of 50 young people less than 45 years old with nonhemorrhagic arterial stroke, three patients had inherited protein C deficiency. CT revealed hypodense areas consistent with the clinical picture, and angiography showed occlusion of some intracranial arterial vessels. Other possible associated causes of stroke were ruled out. One patient had a transient ischemic attack and a peripheral venous thrombosis prior to the actual stroke, whereas the others were completely asymptomatic, as were relatives with the same deficiency. We suggest determining protein C in ischemic stroke of all young adults, especially when major risk factors are excluded.
在连续的50例年龄小于45岁的非出血性动脉性卒中的年轻人中，有3例患者存在遗传性蛋白C缺乏。CT显示与临床表现相符的低密度区，血管造影显示一些颅内动脉血管闭塞。排除了其他可能的卒中相关病因。1例患者在实际卒中前有短暂性脑缺血发作和外周静脉血栓形成，而其他患者完全无症状，具有相同缺陷的亲属也是如此。我们建议对所有年轻成人的缺血性卒中患者测定蛋白C，尤其是在排除主要危险因素时。
