Nowacki P, Zdziarska B
Department of Neurology, School of Medicine, Szczecin, Poland.
Neuropatol Pol. 1993;31(1-2):83-90.
The frequency and distribution of intravascular coagulation (IVC) were studied in brains of 121 patients who had died due to acute myeloblastic leukemias type M1 or M2. The IVC within the brain was observed in 59% of cases, more frequently in patients treated with polychemotherapy, especially according to TAD or VAPA protocols. The microthrombi were found predominantly in capillaries and small venous vessels. IVC was more frequent in cerebral and cerebellar white matter and in the neighbourhood of lateral ventricles (hippocampus, thalamus). In patients who had developed brain hemorrhage in the course of primary neoplasmic disease IVC was very frequent phenomenon, thus IVC is considered to be an important factor in the development of CNS hemorrhages in myeloblastic leukemias, irrespective of thrombocytopenia related to bone marrow involvement.
对121例死于M1或M2型急性髓细胞白血病患者的大脑进行了血管内凝血（IVC）的频率和分布研究。59%的病例在大脑中观察到IVC，在接受多药化疗的患者中更常见，尤其是按照TAD或VAPA方案治疗的患者。微血栓主要见于毛细血管和小静脉血管。IVC在大脑和小脑白质以及侧脑室（海马体、丘脑）附近更常见。在原发性肿瘤疾病过程中发生脑出血的患者中，IVC是非常常见的现象，因此，无论与骨髓受累相关的血小板减少情况如何，IVC被认为是髓细胞白血病中枢神经系统出血发生的一个重要因素。
