Laird W, Groman N
J Virol. 1976 Jul;19(1):228-31. doi: 10.1128/JVI.19.1.228-231.1976.
The orientation of the gene for diphtheria toxin, tox, in the prophage of converting corynebacteriophage beta has been determined. The orientation of tox in prophage and that reported simultaneously by Holmes (1976) for vegetative phage are compatible with the hypothesis that beta phage is inserted into the chromosome of its bacterial host by means of a mechanism similar to that described for lambda phage, and that the phage attachment site lies between the tox and imm genes. The position of three tox mutations that are phenotypically CRM- has also been determined. Relative to the tox-45 mutation, they are located more proximally to the end of the tox structural gene that corresponds to the amino terminal of diphtheria toxin.
已确定产毒素棒状杆菌噬菌体β原噬菌体中白喉毒素基因tox的方向。原噬菌体中tox的方向与霍姆斯（1976年）同时报道的营养噬菌体的方向一致，这与以下假设相符：β噬菌体通过一种类似于λ噬菌体所描述的机制插入其细菌宿主的染色体中，且噬菌体附着位点位于tox和imm基因之间。还确定了三个表型为CRM -的tox突变的位置。相对于tox - 45突变，它们更靠近tox结构基因对应于白喉毒素氨基末端的一端。
