Gonzalez M I, Farabollini F, Albonetti E, Wilson C A
Department of Physiology, University of Madrid, Spain.
Pharmacol Biochem Behav. 1994 Mar;47(3):591-601. doi: 10.1016/0091-3057(94)90164-3.
Two 5-hydroxytryptamine2 (5-HT2) agents, ritanserin and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI) (both at 0.25 mg/kg IP), were administered to castrated males bearing graded testosterone implants (empty, 2.5-, 5-, and 10-mm length) and to normal and neonatally androgenized ovariectomized females bearing 10-mm testosterone implants. The results indicate that testosterone stimulates male sexual behaviour and appears to have a dose-related anxiolytic effect, but no effect on other nonsexual activities. 5-HT and testosterone had opposite effects on male sexual behavior, with ritanserin (5-HT antagonist) enhancing activity in both sexes and DOI (5-HT agonist) inhibiting behaviour in males, the latter being testosterone-dependent. Independent of testosterone, ritanserin reduced locomotion and exploration and increased anxiety in males, while DOI increased locomotion and exploration in both sexes. Ritanserin had a gender-specific effect on anxiety which was independent of testosterone, since in castrated males it was anxiogenic whether they bore testosterone implants or not, while in females it was anxiolytic whether the female were neonatally androgenized (250 micrograms/pup testosterone proprionate [TP] on day 1) or not. These results show that 5-HT and testosterone have opposite effects on male sexual behaviour and these may be interrelated. In adulthood, their effects on nonsexual activities are not inversely related and are independent of each other in contrast to the relationship seen in the neonatal period.
给带有不同长度睾酮植入物（空的、2.5毫米、5毫米和10毫米长）的去势雄性大鼠，以及带有10毫米睾酮植入物的正常和新生期雄激素化的去卵巢雌性大鼠，注射两种5-羟色胺2（5-HT2）药物，利坦色林和1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷盐酸盐（DOI）（均腹腔注射，剂量为0.25毫克/千克）。结果表明，睾酮能刺激性行为，似乎具有剂量相关的抗焦虑作用，但对其他非性行为无影响。5-羟色胺和睾酮对雄性性行为有相反的作用，利坦色林（5-羟色胺拮抗剂）增强两性的活动，而DOI（5-羟色胺激动剂）抑制雄性的行为，后者依赖于睾酮。与睾酮无关，利坦色林减少雄性的运动和探索行为并增加焦虑，而DOI增加两性的运动和探索行为。利坦色林对焦虑有性别特异性作用，且与睾酮无关，因为在去势雄性大鼠中，无论是否带有睾酮植入物，它都具有致焦虑作用，而在雌性大鼠中，无论是否在新生期雄激素化（出生第1天每只幼崽注射250微克丙酸睾酮[TP]），它都具有抗焦虑作用。这些结果表明，5-羟色胺和睾酮对雄性性行为有相反的作用，且这些作用可能相互关联。在成年期，它们对非性行为的影响并非呈相反关系，且相互独立，这与新生期所见的关系不同。
