Padoin M J, Lucion A B
Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Eur J Pharmacol. 1995 Apr 13;277(1):1-6. doi: 10.1016/0014-2999(95)00021-c.
The effects of a 5-HT2 receptor agonist, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane; 0.5 mg/kg), on the behavior of male rats at different ages when given alone or with different levels of testosterone, in the presence of sexually receptive and non-receptive females are presented. DOI increased mounting and/or mount plus thrusting behavior in adult males with receptive females. In pre-pubertal males, DOI increased the frequency of pursuit and genital sniffing in the presence of receptive females, but not of non-receptive ones, when no mounts or thrustings were recorded. In castrated rats treated with testosterone and tested with receptive females, DOI increased the frequency of thrusting behavior, but in castrated rats without testosterone treatment, DOI produced no change. DOI did not induce mounting in pre-pubertal or castrated rats without testosterone substitution therapy. These results suggest that DOI influences male sexual behavior through a neural system that is modulated by testosterone.
本文呈现了5-羟色胺2（5-HT2）受体激动剂DOI（1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷；0.5毫克/千克）在有性接受和无性接受能力的雌性大鼠存在的情况下，单独给药或与不同水平睾酮联合给药时，对不同年龄雄性大鼠行为的影响。DOI增加了成年雄性大鼠在有性接受能力的雌性大鼠面前的爬跨和/或爬跨加抽动行为。在青春期前雄性大鼠中，DOI增加了在有性接受能力的雌性大鼠面前的追逐和生殖器嗅探频率，但在无性接受能力的雌性大鼠面前未增加，且未记录到爬跨或抽动行为。在用睾酮治疗并与有性接受能力的雌性大鼠进行测试的去势大鼠中，DOI增加了抽动行为的频率，但在未用睾酮治疗的去势大鼠中，DOI未产生变化。在未经睾酮替代治疗的青春期前或去势大鼠中，DOI未诱发爬跨行为。这些结果表明，DOI通过一个受睾酮调节的神经系统影响雄性性行为。
