预给水和氟哌啶醇对大鼠的反应率和持续时间有相似的影响。
Prewatering and haloperidol have similar effects on rats' response rate and duration.
作者信息
Jackson D E, Bowen S E
机构信息
Indiana University Northwest, Gary 46408.
出版信息
Pharmacol Biochem Behav. 1994 Mar;47(3):761-3. doi: 10.1016/0091-3057(94)90187-2.
Haloperidol (0.1 mg/kg) and 5-min prewatering were given to 12 rats on three occasions each to determine effects on fixed ratio 15 (FR 15) responding for water. Compared to baseline, both treatments significantly reduced rate (prewatering slightly more) and both significantly increased duration. Though similar, drug and prewatering effects showed enough differences to suggest that there are both anhedonic and motoric deficit components to haloperidol's effects on rats' lever-pressing behavior for water.
给12只大鼠每次给予氟哌啶醇（0.1毫克/千克）并提前5分钟给水，共进行三次，以确定其对固定比率15（FR 15）饮水反应的影响。与基线相比，两种处理均显著降低了反应速率（提前给水的降低幅度稍大），且均显著增加了反应持续时间。虽然药物和提前给水的效果相似，但也表现出足够的差异，表明氟哌啶醇对大鼠压杆获取水行为的影响中既有快感缺失成分，也有运动缺陷成分。
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