Gonçalves E L, Waitzberg D L, Bevilacqua L R, Burger V M
Faculdade de Medicina, Universidade de S. Paulo, SP.
Rev Bras Biol. 1993 Aug;53(3):425-34.
Fecal nitrogen excretion in different nutritional conditions were studied in 32 adult Wistar rats, casually distributed in four groups: group A (12), with normal control rats; group B (6), with subcutaneous impalnt of Walker-256 carcinosarcoma, at the beginning of the experiment; group C (8), with tumor implant eight days before the experiment beginning; group D (6), with standard skin wound in 15th day. The animals were fed with normoproteic diet (25% casein content). Nitrogen ingestion and urinary and fecal excretion were daily measured. Evaluation selected parameters were: nitrogen ingestion and urinary, fecal and total excretion; nitrogen fecal excretion/ingestion, nitrogen fecal excretion/urinary excretion and nitrogen fecal excretion/total excretion ratios; nitrogen urinary excretion/ingestion and nitrogen urinary excretion/total excretion ratios. Adequate statistical analysis was done with p < 0.05 critical limit value. It was observed that in normal animals nitrogen fecal excretion was equal to 5.7% ingestion value, 12.0% urinary excretion and 10.8% total excretion. In presence of malignant tumor, nitrogen fecal excretion was equal to 79% of normal animals value. In rats with skin wound in cicatrization nitrogen fecal excretion was 70.5% of normal animals value.
在32只成年Wistar大鼠中研究了不同营养条件下的粪便氮排泄情况，这些大鼠随机分为四组：A组（12只）为正常对照大鼠；B组（6只）在实验开始时皮下植入Walker-256癌肉瘤；C组（8只）在实验开始前八天植入肿瘤；D组（6只）在第15天有标准皮肤伤口。给动物喂食正常蛋白质饮食（酪蛋白含量25%）。每天测量氮摄入量以及尿液和粪便排泄量。选定的评估参数为：氮摄入量、尿液、粪便和总排泄量；粪便氮排泄量/摄入量、粪便氮排泄量/尿液排泄量和粪便氮排泄量/总排泄量比率；尿液氮排泄量/摄入量和尿液氮排泄量/总排泄量比率。采用p < 0.05的临界限值进行了充分的统计分析。观察到，正常动物的粪便氮排泄量等于摄入量的5.7%、尿液排泄量的12.0%和总排泄量的10.8%。在存在恶性肿瘤的情况下，粪便氮排泄量等于正常动物值的79%。在处于瘢痕形成期皮肤伤口的大鼠中，粪便氮排泄量为正常动物值的70.5%。
