Gonçalves E L, Waitzberg D L, Bevilacqua L R, Bevilacqua R G, Margarido N F, Goffi F S
Department of Surgery, University of São Paulo Medical School, Brazil.
Nutrition. 1989 Nov-Dec;5(6):419-22.
In Wistar rats bearing a Walker-256 carcinoma flank tumor, a standard skin wound was inflicted on the backs of the animals. Nitrogen intake and nitrogen balance measures were obtained. The standard wound did not promote tumor growth. Wound contraction in tumor-bearing animals was not different from that in tumor-free animals. Tumor-bearing rats had anorexia, lower nitrogen intake and a tendency to lower their nitrogen balance. These findings suggest that both cancer and wound healing are privileged metabolic events, having as a consequence sacrifice of the host.
在携带Walker-256癌性胁腹肿瘤的Wistar大鼠身上，在动物背部造成标准皮肤伤口。测量氮摄入量和氮平衡。标准伤口并未促进肿瘤生长。荷瘤动物的伤口收缩与无瘤动物无异。荷瘤大鼠出现厌食、氮摄入量降低以及氮平衡降低的趋势。这些发现表明，癌症和伤口愈合都是特殊的代谢事件，其结果是宿主受到损害。
