Ovalle A, Martínez M A, Casals A, Yuhaniak R, Giglio M S
Departamento y Servicio de Obstetricia y Ginecología, Hospital San Borja Arriarán.
Rev Chil Obstet Ginecol. 1993;58(2):103-12.
Upper genital tract infection was investigated in 46 women admitted to hospital with clinic diagnosis of acute pelvic inflammatory disease (PID) and 62 control women accepted to hospital for laparoscopy Fallopian tubes sterilization. Diagnosis was ratified by laparoscopy in mild and moderate salpingitis; culdocentesis and ultrasonography were performed in severe salpingitis and endometrial sample was made in endometritis. Microbiological specimens were taken from the cervix and abdomen. Antecedents and complete clinical studies were obtained. Patients were treated with antibiotic association sodic G penicillin, chloramphenicol and gentamicin. Risk factors to development PID were: single female (p < 0.05), multiple sexual partner (p < 0.01), previous PID (p < 0.05), infertility (p < 0.05), mean year of IUD use in severe salpingitis (p = 0.05) and mean years of age from women with sexually transmitted bacterias (STB) vs endogenous bacterias (EB) (p < 0.05). In the control group no abdomen bacterias were isolated. In patients with PID, C. trachomatis was detected by serology in 28.3%. N. gonorrhoeae was isolated from the cervix in 23.9% and from the abdomen 17.4%. Besides it was isolated from the abdomen: M. hominis 17.3% and E. coli 15.2%. STB were isolated in 54.3% and EB in 47.8% of the patients. Bacterial association was present on the 37%. Cervix isolation of G. vaginalis and Mycoplasma were not correlated with development of PID. Cervix microbiological samples were useful to know abdomen microbic etiology. They coincide with those in the 90.9%. EB were more frequently isolated from severe salpingitis (p = 0.05) and STB from mild and moderate salpingitis (p = 0.05). Antibiotic association cured all the mild and moderate salpingitis with independence of bacterial etiology. Failure occurred in 2 diffuse peritonitis and 13/14 tubo-ovarian abscesses. Surgery used in severe salpingitis and diffuse peritonitis, principally consisted in anexectomy, peritoneal toilet and drainages. No hysterectomies were performed. Colpotomy drainage was used as a laparotomy complement or as unique drainage. Severe complications of surgery occurred in 10.5%. Failure in antibiotic treatment, surgery and complications were present with preference in PID with EB. After PID 26.5% of women had both Fallopian tubes damaged; in 39.7% tube damage was not evaluated and in 34.2% one tube rested in health. Damage did not depend of bacterial etiology. Conclusion on the necessity of adequate prevention of this disease and it should need education related to the roll of STB and standards about the IUD use.
对46例临床诊断为急性盆腔炎(PID)入院的女性患者以及62例因腹腔镜输卵管绝育术入院的对照女性进行了上生殖道感染调查。轻度和中度输卵管炎通过腹腔镜检查确诊;重度输卵管炎进行后穹窿穿刺和超声检查,子宫内膜炎则取子宫内膜样本。从宫颈和腹部采集微生物标本。获取了患者的既往史和完整的临床研究资料。患者接受了青霉素钠、氯霉素和庆大霉素联合抗生素治疗。PID发生的危险因素有:单身女性(p<0.05)、多个性伴侣(p<0.01)、既往PID(p<0.05)、不孕(p<0.05)、重度输卵管炎患者使用宫内节育器的平均年限(p=0.05)以及感染性传播细菌(STB)与内源性细菌(EB)女性的平均年龄(p<0.05)。对照组未分离出腹部细菌。在PID患者中,28.3%通过血清学检测出沙眼衣原体。23.9%的患者宫颈分离出淋病奈瑟菌,17.4%的患者腹部分离出该菌。此外,从腹部还分离出:人型支原体17.3%,大肠杆菌15.2%。54.3%的患者分离出STB,47.8%的患者分离出EB。37%的患者存在细菌合并感染。阴道加德纳菌和支原体在宫颈的分离与PID的发生无关。宫颈微生物样本有助于了解腹部微生物病因。两者相符率为90.9%。重度输卵管炎中更常分离出EB(p=0.05),轻度和中度输卵管炎中更常分离出STB(p=0.05)。无论细菌病因如何,联合抗生素治愈了所有轻度和中度输卵管炎。2例弥漫性腹膜炎和13/14例输卵管卵巢脓肿治疗失败。重度输卵管炎和弥漫性腹膜炎采用的手术主要包括附件切除术、腹腔冲洗和引流。未进行子宫切除术。阴道切开引流用作剖腹手术的补充或唯一引流方式。手术严重并发症发生率为10.5%。抗生素治疗失败、手术及并发症在EB引起的PID中更常见。PID后,26.5%的女性双侧输卵管受损;39.7%未评估输卵管损伤情况,34.2%一侧输卵管健康。损伤与细菌病因无关。结论强调了充分预防该疾病的必要性,应开展与STB作用及宫内节育器使用标准相关的教育。