Martínez-Abraján D M
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., Mexico.
Rev Latinoam Microbiol. 1993 Apr-Jun;35(2):171-6.
C57BL/6 and BALB/c mouse strains were infected intraperitoneally with 10(8) Mycobacterium lepraemurium (MLM). At various stages of the infection, MLM-specific IgM, IgG, IgG1 and IgG2a serum antibodies were assessed. Anti-MLM antibody response varied markedly in both strains, in terms of antibody titres, Ig class distribution and kinetics of antibody secretion. C57BL/6 mice, which show intermediate resistance to MLM infection, presented the higher titres of IgM and IgG specific antibody, but without anti-MLM IgG1 detectable production. On the other hand, BALB/c susceptible strain showed a delayed but high IgG1 antibody production. Since it has been reported that Th2 lymphocyte subset modulate IgG1 antibody production, our results may reflect a differential activation of Th1 and Th2 cell subsets in both strains during a MLM infection.
将C57BL/6和BALB/c小鼠品系经腹腔注射10⁸ 鼠麻风杆菌（MLM）进行感染。在感染的不同阶段，评估了MLM特异性IgM、IgG、IgG1和IgG2a血清抗体。两种品系中抗MLM抗体反应在抗体滴度、Ig类别分布和抗体分泌动力学方面均有显著差异。对MLM感染表现出中等抵抗力的C57BL/6小鼠，呈现出较高滴度的IgM和IgG特异性抗体，但未检测到抗MLM IgG1的产生。另一方面，易感的BALB/c品系显示出延迟但高水平的IgG1抗体产生。由于已有报道Th2淋巴细胞亚群调节IgG1抗体的产生，我们的结果可能反映了在MLM感染期间两种品系中Th1和Th2细胞亚群的不同激活情况。
