Pedersen G, Larsen N H, Schønheyder H C, Pedersen M, Rosdahl V T, Jepsen O B
Klinisk mikrobiologisk afdeling, Aalborg Sygehus.
Ugeskr Laeger. 1994 Apr 4;156(14):2065-6, 2069-70.
In Denmark, strains of methicillin-resistant (MR) Staphylococcus aureus constitute less than 0.1% of all S. aureus isolates and are often acquired abroad. A strain of MR S. aureus phage type 77+ was isolated from a patient, who had been hospitalized in a Portuguese hospital three months earlier. In Denmark, the patient had been admitted to a private clinic for replacement of the aortic valve and a coronary bypass operation. The strain did not produce detectable soluble coagulase, and it was multiply resistant, including resistance to gentamicin, tetracycline, erythromycin, and rifampicin. It was probably non-invasive. Thirty-seven members of the staff were screened for MR S. aureus with negative results. The patient was treated with chlorhexidine to eliminate carriage, but, eight weeks after treatment, he was still colonized. Thus, in the current epidemiological situation in Denmark, it is important to take into consideration that carriage of MR S. aureus may last several months. We therefore suggest, that specific guidelines for hospital hygiene should be upheld not only for patients, who are transferred directly from hospitals in other countries, but also for patients, who have been hospitalized abroad within the last three to six months.
在丹麦，耐甲氧西林金黄色葡萄球菌菌株在所有金黄色葡萄球菌分离株中所占比例不到0.1%，且通常是从国外感染的。一株77 +型耐甲氧西林金黄色葡萄球菌从一名患者身上分离出来，该患者三个月前曾在一家葡萄牙医院住院。在丹麦，该患者因主动脉瓣置换和冠状动脉搭桥手术入住一家私立诊所。该菌株未产生可检测到的可溶性凝固酶，并且具有多重耐药性，包括对庆大霉素、四环素、红霉素和利福平耐药。它可能不具有侵袭性。对37名工作人员进行了耐甲氧西林金黄色葡萄球菌筛查，结果均为阴性。该患者接受了洗必泰治疗以消除携带状态，但治疗八周后，他仍处于定植状态。因此，在丹麦当前的流行病学形势下，必须考虑到耐甲氧西林金黄色葡萄球菌的携带状态可能会持续数月。我们因此建议，不仅对于直接从其他国家医院转来的患者，而且对于过去三到六个月内在国外住院的患者，都应坚持执行医院卫生的具体指导原则。
