Lindsey R W, Miclau T, Probe R, Perren S
Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, Texas.
Yale J Biol Med. 1993 May-Jun;66(3):157-63.
The in-vivo study of bone graft incorporation has traditionally used a segmental diaphyseal bone defect. This model reliably produces a nonunion, but is complicated by graft instability and altered limb loading stresses. The authors discuss the advantages of a defect-in-continuity canine femur model which produces a more consistent union with fewer mechanical complications despite the absence of fixation. This proposed model permits analysis of radiographic, histologic and biomechanical data which are more applicable to the usual clinical setting in which bone graft is required.
传统上，骨移植融合的体内研究采用节段性骨干骨缺损模型。该模型能可靠地导致骨不连，但存在移植物不稳定和肢体负荷应力改变等问题。作者讨论了连续性缺损犬股骨模型的优点，尽管没有固定，但该模型能产生更一致的融合且机械并发症更少。这个提议的模型允许分析放射学、组织学和生物力学数据，这些数据更适用于需要骨移植的常见临床情况。
