Weiss A, Weiss B
MMW Munch Med Wochenschr. 1976 Jul 2;118(27):875-8.
The cytotoxic and alkylating substance, mustard gas, causes both acute poisoning and also damage to numerous organs following chronic exposure. Especially important is the carcinogenic effect, also confirmed in humans. 34 years after occupational exposure to mustard gas with many intoxication episodes, a former munition-worker died of a glioblastoma; two years before his death a neurofibroma was detected in the thorax and removed by operation. The causal connection between the mustard gas exposure and the development of two neurogenic tumors rests on the statistically significantly raised frequency of malignant tumors and the established psychic changes in former workers with mustard gas and especially on the production of malignant tumors of the central nervous system in experimental animals with alkylating nitrosamines.
细胞毒性和烷化剂芥子气会导致急性中毒，长期接触后还会对多个器官造成损害。尤其重要的是其致癌作用，这在人类身上也得到了证实。在职业性接触芥子气并经历多次中毒事件34年后，一名前弹药工人死于胶质母细胞瘤；在他去世前两年，胸部检测到一个神经纤维瘤并通过手术切除。芥子气暴露与两种神经源性肿瘤的发生之间的因果关系基于恶性肿瘤发生频率在统计学上显著升高以及芥子气接触工人已确定的精神变化，特别是基于用烷基化亚硝胺处理的实验动物中中枢神经系统恶性肿瘤的产生。
