Weiss A, Weiss B
Dtsch Med Wochenschr. 1975 Apr 25;100(17):919-23. doi: 10.1055/s-0028-1106315.
Sulphur-mustard and nitrogen-mustard are known to act as carcinogens in animal experiments. A similar effect in humans was demonstrated in 245 workers previously exposed occupationally to mustard gas and followed for over 20 years. There was a statistically significant increase in malignant tumours, especially bronchial carcinoma, bladder carcinoma and leukaemia. These findings underline the need for using alkylating agents of the mustard type exclusively in the treatment of malignant neoplasms. Immunosuppression with alkylating agents in the treatment of chronic inflammatory diseases associated with a long life expectancy is no longer justified.
已知硫芥和氮芥在动物实验中具有致癌作用。在245名曾职业性接触芥子气并随访20多年的工人中，也证实了人类存在类似效应。恶性肿瘤，尤其是支气管癌、膀胱癌和白血病的发病率在统计学上有显著增加。这些发现强调，仅应在治疗恶性肿瘤时使用芥子类烷化剂。在治疗预期寿命较长的慢性炎症性疾病时，使用烷化剂进行免疫抑制已不再合理。
