So C S, Volger E
MMW Munch Med Wochenschr. 1976 Jul 2;118(27):889-92.
24 patients with bradycardiac arrhythmias of various origin were treated with a new depot preparation of orciprenaline. The special galenical preparation guarantees effectiveness ofr 8-10 hours. In 21 patients (87%), therefore, one dragee morning and evening was sufficient to obtain a mean rise in frequency of 57%. The preparation had to be discontinued in 3 cases because of side effects such as increase in ventricular extrasystoles, anginal complaints and critical rise of blood pressure in hypertension. Because of its trouble-free administration in a depot form the preparation not only offers a practical advantage over the short-acting commercial preparations, but also shows a reliable efficacy. It can therefore be given under regular supervision in all forms of bradycardiac arrhythmias with stable ventricular frequency and satisfactory cardiac output.
24例不同病因的缓慢性心律失常患者接受了新的奥西那林长效制剂治疗。这种特殊的药剂学制剂可保证8至10小时的疗效。因此，21例患者（87%）早晚各服用一粒糖衣丸就足以使心率平均提高57%。3例患者因出现副作用，如室性早搏增多、心绞痛症状以及高血压患者血压急剧升高，而不得不停药。由于该制剂以长效剂型给药，使用方便，不仅比短效市售制剂具有实际优势，而且疗效可靠。因此，在心室率稳定、心输出量满意的各种缓慢性心律失常患者中，可在常规监测下使用该制剂。
