Langrehr J M, Markus P M, Banner B, Lee K K, Schraut W H
Department of Surgery, School of Medicine University of Pittsburgh, Pennsylvania 15261.
Am J Surg. 1994 Jun;167(6):579-85. doi: 10.1016/0002-9610(94)90102-3.
The recent success in controlling acute rejection in clinical small bowel transplantation has resulted in a number of patients with functioning grafts and an occasional occurrence of graft-versus-host disease (GVHD). To better understand this complication following small bowel transplantation, a model of chronic GVHD was developed, using the Brown Norway-->Lewis rat strain combination. When the Lewis recipients were immunocompromised at the time of transplantation and received a graft specifically sensitized against Lewis, fatal GVHD developed in 3 of 5 animals. Serial histologic evaluation and determination of donor major histocompatibility complex (MHC) class I antigens were used to delineate the course of GVHD. Although the histologic results were inconsistent, with the exception of the animals developing fatal GVHD, the detection of donor MHC antigens correlated well with the development of GVHD. Determination of donor MHC class I antigens may serve as useful indicators for the development of GVHD.
临床小肠移植在控制急性排斥反应方面最近取得的成功，使得许多患者的移植肠功能良好，且偶尔会发生移植物抗宿主病（GVHD）。为了更好地理解小肠移植后的这种并发症，利用布朗挪威大鼠→刘易斯大鼠品系组合建立了慢性GVHD模型。当刘易斯受体在移植时免疫功能低下，并接受了对刘易斯具有特异性致敏作用的移植物时，5只动物中有3只发生了致命的GVHD。采用连续组织学评估和供体主要组织相容性复合体（MHC）I类抗原测定来描绘GVHD的病程。虽然组织学结果不一致，但除了发生致命GVHD的动物外，供体MHC抗原的检测与GVHD的发生密切相关。供体MHC I类抗原的测定可能是GVHD发生的有用指标。
