Shchedrina R N, Nazarenko T A, Kolod'ko V G, Mullabaeva S M, Efremova L D, Kiriushkin A V
Akush Ginekol (Mosk). 1994(1):38-41.
Clinico-hormonal parameters of cycles stimulated with human menopausal gonadotropins in patients with hypogonadotropic amenorrhea and of spontaneous cycles in healthy women of reproductive age are compared. Estradiol hypersecretion in both phases of induced cycle was revealed: hydrocortisone in phase 1 and progesterone and testosterone in phase 2. Dexamethasone in daily dose 0.25 mg was administered for correction. This resulted in a noticeable reduction of estradiol hyperproduction in the first phase of stimulated cycles and in hyperandrogenism elimination. Folliculogenesis, ovulation, and early embryogenesis conditions in schemes of induction with human menopausal gonadotropins and dexamethasone therapy were close to physiologic ones, this resulting in increased share of fertile cycles.
比较了低促性腺激素性闭经患者使用人绝经期促性腺激素刺激周期的临床激素参数与育龄健康女性自发周期的临床激素参数。发现在诱导周期的两个阶段均存在雌二醇分泌过多的情况：在第1阶段为氢化可的松，在第2阶段为孕酮和睾酮。给予每日剂量0.25mg的地塞米松进行纠正。这导致刺激周期第一阶段雌二醇过度产生明显减少，并消除了高雄激素血症。人绝经期促性腺激素诱导方案和地塞米松治疗中的卵泡生成、排卵及早期胚胎发生情况接近生理状态，这使得可育周期的比例增加。
