Jefferis R, Pound J, Lund J, Goodall M
Department of Immunology, Medical School, Edgbaston, Birmingham, UK.
Ann Biol Clin (Paris). 1994;52(1):57-65.
Secondary systemic immune responses are predominantly of the IgG class and passive administration of intravenous IgG, from pooled normal serum, is an effective prophylactic and/or therapeutic treatment for patients with defined immunodeficiencies. However, the proportions of each IgG subclass present within a specific antibody response may differ dramatically from that of the total IgG pool. For some antigens the response may be essentially restricted to a single subclass and it may be presumed that the antibody isotype produced has an optimal protective role. The clinical consequences of selective IgG subclass deficiency appears to validate this presumption. In this review we emphasize the differences in effector functions activated by the IgG subclasses and hence the mechanisms responsible for the removal and destruction of antigen/antibody complexes. These studies are relevant to diagnosis and treatment of patients with recurrent infection; the IgG isotype of monoclonal antibodies selected for passive in vivo therapy; the generation of customized antibodies having a pre-determined profile of effector functions and 'immuno-direction' with new vaccines to provoke an antibody response having an isotype profile optimal for the proposed application.
二次全身性免疫反应主要为IgG类，静脉注射从混合正常血清中提取的IgG对特定免疫缺陷患者是一种有效的预防性和/或治疗性疗法。然而，特定抗体反应中存在的每个IgG亚类的比例可能与总IgG库的比例有很大差异。对于某些抗原，反应可能基本上局限于单个亚类，可以推测所产生的抗体同种型具有最佳保护作用。选择性IgG亚类缺陷的临床后果似乎证实了这一推测。在本综述中，我们强调了由IgG亚类激活的效应功能的差异，以及负责清除和破坏抗原/抗体复合物的机制。这些研究与复发性感染患者的诊断和治疗相关；用于体内被动治疗的单克隆抗体的IgG同种型；具有预定效应功能谱的定制抗体的产生，以及通过新疫苗进行“免疫导向”以引发具有最适合拟用应用的同种型谱的抗体反应。
