Schultz R T, Cho N K, Staib L H, Kier L E, Fletcher J M, Shaywitz S E, Shankweiler D P, Katz L, Gore J C, Duncan J S
Child Study Centre, Yale University School of Medicine, New Haven, CT.
Ann Neurol. 1994 Jun;35(6):732-42. doi: 10.1002/ana.410350615.
Morphometric magnetic resonance imaging techniques were used to compare the convolutional surface area of the planum temporale, temporal lobe volume and superior surface area, and an estimate of overall brain volume in a homogeneous sample of 17 dyslexic children (7 girls) and 14 nonimpaired children (7 girls). Substantial sex differences were apparent for all measured regions, with all the measurements in boys being significantly larger. Age, even within the narrow range employed here (7.5-9.7 years), was positively correlated with the size of each brain region. While initial analyses suggested smaller left hemisphere structures in dyslexics compared to control subjects, subsequent analyses controlling for age and overall brain size revealed no significant differences between dyslexics and nonimpaired children on a variety of measures, in particular surface area and symmetry of the planum temporale. We suggest that differences in subject characteristics (i.e., sex, age, handedness, and definition of dyslexia) as well as procedural variations in the methods used to acquire images and to define and measure anatomical regions of interest such as the planum temporale all may play an important role in explaining apparent discrepant results in the neuroimaging literature on dyslexia.
采用形态测量磁共振成像技术，对17名诵读困难儿童（7名女孩）和14名非受损儿童（7名女孩）的同质样本进行颞平面的脑回表面积、颞叶体积和上表面积比较，并估算全脑体积。所有测量区域均存在明显的性别差异，男孩的所有测量值均显著更大。年龄，即使在本文所采用的狭窄范围内（7.5 - 9.7岁），也与每个脑区的大小呈正相关。虽然初步分析表明诵读困难儿童的左半球结构比对照组小，但随后控制年龄和全脑大小的分析显示，在各种测量指标上，尤其是颞平面的表面积和对称性方面，诵读困难儿童与非受损儿童之间没有显著差异。我们认为，受试者特征（即性别、年龄、利手和诵读困难的定义）的差异，以及用于获取图像和定义及测量感兴趣的解剖区域（如颞平面）的方法中的程序变化，都可能在解释诵读困难神经影像学文献中明显不一致的结果方面发挥重要作用。
