Takahashi S, Higano S, Ishii K, Matsumoto K, Sakamoto K, Iwasaki Y, Suzuki M
Department of Radiology, Tohoku University School of Medicine, Sendai, Japan.
Radiology. 1993 Nov;189(2):449-56. doi: 10.1148/radiology.189.2.8210374.
To report the findings of sequential magnetic resonance (MR) imaging in hypoxic encephalopathy.
Three women and three men underwent repeated MR imaging studies. Sequential changes in signal intensity and morphologic features of the brain were evaluated.
Involvement of the watershed zones in the parietooccipitotemporal cortex was more frequent and more severe than that in the basal ganglia, thalami, hippocampus, pons, and cerebellum. Cerebral edema was seen in the acute stage. Enhanced T1-weighted images showed cortical laminar enhancement in the early subacute stage; unenhanced T1-weighted images revealed characteristic laminar hyperintense lesions of the cerebral cortex in the late subacute stage. Both of these findings seemed to reflect the progression of cortical laminar necrosis. In the chronic stage, cortical atrophy and delayed but progressive white matter changes were seen.
Changes in MR imaging features of hypoxic brain damage are complex but distinct. Cortical laminar necrosis, delayed white matter degeneration, and, probably, increased iron deposition in the white matter can be delineated.
报告缺氧性脑病的系列磁共振（MR）成像结果。
对3名女性和3名男性进行了重复的MR成像研究。评估了大脑信号强度和形态学特征的系列变化。
顶枕颞叶皮质分水岭区受累比基底节、丘脑、海马、脑桥和小脑更频繁、更严重。急性期可见脑水肿。增强T1加权图像在亚急性早期显示皮质层状强化；未增强T1加权图像在亚急性晚期显示大脑皮质特征性的层状高信号病变。这两个发现似乎都反映了皮质层状坏死的进展。在慢性期，可见皮质萎缩和延迟但进行性的白质改变。
缺氧性脑损伤的MR成像特征变化复杂但具有特征性。可明确皮质层状坏死、延迟性白质变性，以及可能的白质中铁沉积增加。
