分次照射后恶性胶质瘤细胞系的球体控制：与2 Gy时的存活分数及软琼脂克隆形成试验中的集落形成效率的关系
Spheroid control of malignant glioma cell lines after fractionated irradiation: relation to the surviving fractions at 2 Gy and colony forming efficiencies in a soft agar clonogenic assay.
作者信息
Stuschke M, Budach V, Kalff R L, Sack H, Bamberg M, Reinhardt V, Feldmann H J
机构信息
Department of Radiotherapy, University of Essen, Germany.
出版信息
Radiother Oncol. 1993 Jun;27(3):245-51. doi: 10.1016/0167-8140(93)90081-i.
Spheroid control doses (SCD50) were determined for ten human glioma lines after fractionated irradiation under oxic conditions. In addition, SF2 values and colony forming efficiencies (CFE) were measured in a soft agarose clonogenic assay. A significant relationship existed between the SCD50 values and the SF2-CFE data pairs (p = 0.01) but the SCD50 values were higher than expected from the SF2 and CFE values. This comparison shows the influence of environmental factors (different in both model systems) on reproductive tumour cell death after irradiation.
在有氧条件下对十个人类胶质瘤细胞系进行分次照射后，测定了球体对照剂量（SCD50）。此外，在软琼脂克隆形成试验中测量了SF2值和集落形成效率（CFE）。SCD50值与SF2-CFE数据对之间存在显著相关性（p = 0.01），但SCD50值高于根据SF2和CFE值预期的结果。该比较显示了环境因素（两种模型系统中不同）对照射后肿瘤生殖细胞死亡的影响。
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