Jastrzebski Z, Goźlińska B, Czyzewska-Szafran H
Department of Pharmacology, Institute of Drug Research and Control, Warsaw, Poland.
Res Commun Chem Pathol Pharmacol. 1993 Jul;81(1):113-6.
The effect of the GABA agonist muscimol on the hypotensive action of clonidine in SHR was investigated. Muscimol administered before clonidine significantly (p < 0.01) intensified clonidine-induced reduction of blood pressure. This effect was achieved at muscimol doses which themselves had no influence on blood pressure. Muscimol injected after clonidine was ineffective. Our data suggest that the muscimol-clonidine interaction occurs at the level of GABAergic neurotransmission since both agents have been proved to activate the function of GABAergic neurons.
研究了γ-氨基丁酸（GABA）激动剂蝇蕈醇对自发性高血压大鼠（SHR）可乐定降压作用的影响。在给予可乐定之前给予蝇蕈醇，可显著（p<0.01）增强可乐定引起的血压降低。在蝇蕈醇剂量本身对血压无影响的情况下即可实现此效应。在给予可乐定之后注射蝇蕈醇则无效。我们的数据表明，蝇蕈醇与可乐定的相互作用发生在GABA能神经传递水平，因为已证明这两种药物均可激活GABA能神经元的功能。
