Iwasaki K, Shiraga T, Takeshita K, Katashima M, Nagase K, Tada K, Noda K, Noguchi H
Department of Pharmacokinetics and Drug Metabolism, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
Res Commun Chem Pathol Pharmacol. 1993 Aug;81(2):183-90.
Development of the sulfoconjugating activities for amine, alcoholic and phenolic compounds was studied in hepatic 105,000 g supernatants of fetal and newborn rats. All activities in the fetus at the late stage of pregnancy were negligible or very low when compared with those of the adult female level. Amine and alcohol sulfoconjugating activities were low 2 days after birth, increased with age, and attained the adult female level 17 days after birth. In contrast, phenol sulfoconjugating activity was nearly half the level of adult female rats in the neonates 2 days after birth and was relatively constant before maturation. There were no sex-related differences in any of the activities in the immature rats, but in adult animals the activities for amine and alcohol were higher in the females than in the males; the opposite was observed for phenol sulfoconjugation.
在胎鼠和新生大鼠肝脏105,000g上清液中研究了胺类、醇类和酚类化合物硫酸结合活性的发育情况。与成年雌性大鼠的水平相比，妊娠后期胎儿的所有活性均可忽略不计或非常低。胺类和醇类硫酸结合活性在出生后2天较低，随年龄增长而增加，并在出生后17天达到成年雌性大鼠的水平。相比之下，出生后2天新生大鼠的酚类硫酸结合活性几乎是成年雌性大鼠水平的一半，并且在成熟之前相对稳定。未成熟大鼠的任何活性均无性别相关差异，但在成年动物中，雌性大鼠的胺类和醇类活性高于雄性；酚类硫酸结合则观察到相反的情况。
