Yamamoto M, Sakamoto N, Iwai A, Yatsugi S, Hidaka K, Noguchi K, Yuasa T
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Res Commun Chem Pathol Pharmacol. 1993 Aug;81(2):221-32.
Effects of YM737[N-(N-r-L-glutamyl-L-cysteinyl)glycine 1-isopropyl ester sulfate monohydrate], a new glutathione (GSH) analog more readily transported into cells than GSH, on cerebral ischemia were compared with those of GSH and some other drugs in rats subjected to occlusion of the bilateral carotid arteries. YM737 significantly reduced lethality, increased brain-water levels as measured by both dry-wet and NMR methods, and increased malondialdehyde (MDA) levels in the cerebral ischemic rats. On the other hand, pharmacological actions of GSH itself was less than those of YM737. In the ischemic rats used in the present study, there was no significant difference in 31P-NMR signals between the normal and the cerebral ischemic rats. These results suggest that YM737 showed anti-cerebral ischemic effects presumably due, in part, to inhibition of lipid peroxidative responses.
将新型谷胱甘肽（GSH）类似物YM737[N-（N-r-L-谷氨酰-L-半胱氨酰）甘氨酸1-异丙酯硫酸盐水合物]与GSH及其他一些药物对双侧颈动脉闭塞大鼠脑缺血的影响进行了比较。与GSH相比，YM737更易转运入细胞。YM737显著降低了脑缺血大鼠的死亡率，通过干湿法和核磁共振法测得其脑含水量增加，丙二醛（MDA）水平升高。另一方面，GSH本身的药理作用小于YM737。在本研究中使用的缺血大鼠中，正常大鼠与脑缺血大鼠之间的31P-核磁共振信号无显著差异。这些结果表明，YM737显示出抗脑缺血作用，可能部分归因于对脂质过氧化反应的抑制。
