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[结核病:1991/92年的诊断与耐药发生率]

[Tuberculosis: diagnosis and incidence of resistance 1991/92].

作者信息

Pfyffer G E

机构信息

Nationales Zentrum für Mykobakterien, Universität Zürich.

出版信息

Schweiz Rundsch Med Prax. 1993 Oct 5;82(40):1090-4.

PMID:8210877
Abstract

In the past few years new diagnostic strategies have considerably cut down the turnaround time for detection, identification and susceptibility testing of mycobacteria. Highly sensitive methods (e.g., gene probes, PCR, gas liquid chromatography/mass spectrometry) will further improve rapid and accurate laboratory testing. They which all aim at a direct detection of mycobacteria in clinical specimens. In a brief survey conducted by the NZM/IMM susceptibility data of M. tuberculosis isolates in Switzerland were obtained from 14 laboratories. As expected, the great majority of the strains exhibit full sensitivity against the primary antituberculous drugs. The patterns as well as the percentages of resistance for the period between January 1991 to June 1992 do not differ significantly from the results obtained in an earlier investigation.

摘要

在过去几年中,新的诊断策略已大幅缩短了分枝杆菌检测、鉴定及药敏试验的周转时间。高灵敏度方法(如基因探针、聚合酶链反应、气相色谱/质谱联用)将进一步改善快速、准确的实验室检测。这些方法均旨在直接检测临床标本中的分枝杆菌。在新西兰微生物学会/免疫学会进行的一项简短调查中,从瑞士14个实验室获得了结核分枝杆菌分离株的药敏数据。不出所料,绝大多数菌株对一线抗结核药物表现出完全敏感性。1991年1月至1992年6月期间的耐药模式及耐药百分比与早期调查结果相比无显著差异。

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