Rebar A H
School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1240.
Toxicol Pathol. 1993;21(2):118-29. doi: 10.1177/019262339302100202.
Hematologic responses in a toxicologic setting may be quite complex and may involve both local as well as systemic manifestations of toxicity and/or pharmacologic responses. Direct toxicity to bone marrow can lead to changes such as marrow necrosis, marrow dysplasia, and macrophage hyperplasia. Some toxic compounds can directly stimulate or suppress the development of 1 or more marrow cell lines. The marrow may also respond to injury at distant sites with increased production of various blood cell elements. Accurate interpretation of hematologic responses generally involves integration of peripheral blood data with bone marrow findings as well as toxicologic findings in other organ systems. This manuscript overviews the various marrow changes encountered in toxicologic studies and provides a perspective of how these changes are best approached from an interpretive viewpoint.
在毒理学环境中的血液学反应可能相当复杂，可能涉及毒性和/或药理反应的局部及全身表现。对骨髓的直接毒性可导致诸如骨髓坏死、骨髓发育异常和巨噬细胞增生等变化。一些有毒化合物可直接刺激或抑制一种或多种骨髓细胞系的发育。骨髓也可能对远处部位的损伤作出反应，增加各种血细胞成分的生成。血液学反应的准确解释通常需要将外周血数据与骨髓检查结果以及其他器官系统的毒理学检查结果相结合。本文概述了毒理学研究中遇到的各种骨髓变化，并从解释的角度提供了如何最好地处理这些变化的观点。
