Chan R C, Shukovsky L J
Radiology. 1976 Sep;120(3):673-5. doi: 10.1148/120.3.673.
From 1954 through 1971, 47 patients with malignant tumors of the nasal cavity and paranasal sinuses were treated with an entire eye included in the tumor dose volume. All patients were treated with megavoltage radiation and received approximately 6,000 rads in 30 fractions in six weeks. Two thirds of the patients treated by irradiation alone had no problems with vision or difficulties related to treatment of the eye. When 5-fluorouracil (5-FU) was used in conjunction with high-dose radiotherapy, loss of vision was much more frequent and all patients had either visual loss or major clinical difficulties.
从1954年到1971年，47例鼻腔和鼻窦恶性肿瘤患者接受了治疗，肿瘤剂量体积包括整个眼睛。所有患者均接受兆伏级放疗，在六周内分30次给予约6000拉德的剂量。仅接受放疗的患者中有三分之二没有视力问题或与眼部治疗相关的困难。当5-氟尿嘧啶（5-FU）与高剂量放疗联合使用时，视力丧失更为常见，所有患者均出现视力丧失或严重的临床困难。
